7.6 Interactions
Acetazolamide - administration may increase serum
concentration of amphetamine.
Alcohol - may increase serum concentration of amphetamine.
Ascorbic acid -lowering urinary pH, may enhance amphetamine
excretion
Furazolidone - amphetamines may induce a hypertensive
response in patients taking furazolidone.
Guanethidine - amphetamine inhibits the antihypertensive
response to guanethidine.
Haloperidol - limited evidence indicates that haloperidol may
inhibit the effects of amphetamine but the clinical
importance of this interaction is not established.
Lithium carbonate - isolated case reports indicate that
lithium may inhibit the effects of amphetamine.
Monoamine oxidase inhibitor - severe hypertensive reactions
have followed the administration of amphetamines to patients
taking monoamine oxidase inhibitors.
Noradrenaline - amphetamine abuse may enhance the pressor
response to noradrenaline.
Phenothiazines - amphetamine may inhibit the antipsychotic
effect of phenothiazines, and phenothiazines may inhibit the
anorectic effect of amphetamines.
Sodium bicarbonate - large doses of sodium bicarbonate
inhibit the elimination of amphetamine, thus increasing the
amphetamine effect.
Tobacco smoking - amphetamine appears to induce dose-related
increases in cigarette smoking.
Tricyclic antidepressants - theoretically increases the
effect of amphetamine, but clinical evidence is lacking.
(Stockley, 1994; Dollery, 1991)
